Taken with meals
ClearDose Digestive Enzymes with Probiotics
A twice-a-day capsule of fungal and fruit digestive enzymes with three Lactobacillus species, taken before meals.
- Format
- Capsule
- Type
- Digestive enzyme and probiotic
- Cost
- $1.47 a day
- Customer rating
- 4.1 out of 5 from 187 ratings from Amazon
What customers consistently report
- Fewer urgent bathroom trips after gallbladder removal or with IBS-D
- An effect within days to a few weeks
- Quick replies from customer support
Those are the themes that recur across the reviews. Low review confidence — Amazon shows 4.1 from 187 ratings and Trustpilot 4.3 from 67 reviews, but the brand’s own pages quote 4.4 from over 21,500 customers and 4.7 from 190-plus reviews while its widget shows 84, and the ads that send traffic to the site use narrators who could not be matched to real people.
Why it might work
Enzymes are meant to break down protein, fat, lactose and certain carbohydrates in the small intestine so less undigested food reaches the colon. The blend includes a fungal protease, bromelain from pineapple, papain from papaya, a fungal lipase, a fungal lactase and alpha-galactosidase for bean sugars. The brand says the three Lactobacillus species help the gut lining recover, but gives no strain or dose. Diarrhea has many causes, including bile acids after gallbladder removal, which enzymes do not bind, and the label cannot show which cause a buyer has. The label directs one capsule 20 to 30 minutes before a meal, twice a day.
What the research supports
No trial of this product was found. Fecal elastase studies put severe pancreatic enzyme insufficiency at roughly 2 to 6 percent of people with IBS-D, and the improvement reported with enzymes in those studies was for prescription pancreatic extract, not a fungal and fruit-enzyme blend. Alpha-galactosidase, which this label carries at 300 GALU a capsule, reduced gas and flatulence after bean meals in small trials, and the three Lactobacillus species are named without strains or counts.
What the label discloses
The enzymes are printed with activity units (for example lipase 1,500 FIP and lactase 600 LACU per capsule), but the protease and the three Lactobacillus species share one 400 mg Makzyme-Pro figure with no CFU count, while the brand’s own page says it uses no proprietary blends. The brand states third-party testing and an FDA-registered US facility without naming a laboratory or showing a certificate. The label is shown only in the Amazon listing, not on the brand’s own page.
Who this tends to suit
We match this product to people reporting bloating, gas, loose stools, urgency and symptoms that follow particular foods. It fits someone whose priority is day-to-day comfort or handling meals. Whether it is the best fit for you depends on the rest of your answers — what you have already tried, what format you will take, and anything that has to be ruled out.
Where it may not fit
The label supports gluten-free and dairy-free. We flag this product for anyone pregnant or breastfeeding or taking prescription medication, and the quiz removes it rather than recommending it in those cases. That is a caution about who should be deciding, not a claim about the product. A capsule only works if you will take it as often as the label directs.
Side effects and what to be aware of
Reviews are mostly positive on the brand’s own pages, with a minority reporting no effect, worse diarrhea or constipation, and, on Trustpilot, refund requests that went unanswered. The written refund policy requires 60 days of consistent use even though ads say no questions asked, and the product page opens with a three-bottle subscription selected. The brand’s questions page advises talking to a doctor or pharmacist first if taking prescription medicines; the bottle’s warnings were not legible in any image read.
Common questions
Does ClearDose Digestive Enzymes work?
No trial of ClearDose itself was found. Studies of enzyme replacement show benefit mainly in the 2 to 6 percent of IBS-D patients with measured pancreatic insufficiency, using prescription pancreatic enzymes, and alpha-galactosidase reduced gas after bean meals in small trials. Amazon shows 4.1 from 187 ratings; some reviewers report fewer urgent trips within days and others report no change or worse symptoms.
Is ClearDose safe, and what are its side effects?
The brand describes it as plant-based with no laxatives or stimulants and advises checking with a doctor or pharmacist if taking prescription medicines. Most reviewers report no problems, but a few report diarrhea getting worse, constipation or discomfort within a day or two. The label does not name the probiotic strains or counts, and bromelain and papain are pineapple- and papaya-derived enzymes.
ClearDose vs a prescription enzyme such as Creon: is it the same?
No. Prescription pancreatic enzyme replacement is a different product with measured lipase, protease and amylase doses, given for diagnosed pancreatic insufficiency. ClearDose is a dietary supplement of fungal and fruit enzymes plus three Lactobacillus species; its label lists 1,500 FIP lipase per capsule and no amylase, and no study compares the two.
How much does ClearDose cost?
One 60-capsule bottle is $53.00 on the brand’s site, which is $1.77 a day at two capsules a day, and $44.00 on Amazon ($1.47 a day). The site preselects a three-bottle subscription at $95.40 every three months ($1.06 a day); unticking Subscribe and Save shows one-time prices of $53, $106 and $159.
What is the ClearDose refund policy?
ClearDose LLC lists a Houston, Texas address, sells on Amazon and has a Trustpilot profile (4.3 from 67 reviews). The written policy refunds within 90 days of delivery only if the product was used consistently for at least 60 days, which differs from the no-questions-asked wording in ads; a few Trustpilot reviewers say refund requests went unanswered and one says a card chargeback was needed. The long first-person ads use narrators who could not be matched to real people.
Before you take this. Speak to a doctor or pharmacist first if you are pregnant or breastfeeding, or taking prescription medication. Nothing on this page is medical advice, and no supplement diagnoses, treats, cures or prevents disease.
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Others we researched for the same job
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Related reading
Background on how this type of product works, read from the trial evidence.