Taken with meals
BIOptimizers MassZymes
A multi-enzyme capsule built around protease, with amylase, lipases and lactase, taken one to three at a time with meals.
- Format
- Capsule
- Type
- Digestive enzyme
- Cost
- $0.86 a day
- Customer rating
- 4.5 out of 5 from 2,596 ratings from Amazon
What customers consistently report
- Feeling lighter and less bloated after meals
- Handling meat and high-protein meals
- A wide range of enzymes in each capsule
Those are the themes that recur across the reviews. Moderate review confidence — Amazon’s 4.5 from 2,596 ratings is independent, while the brand’s 4.7 from 352 is a widget on its own page and Trustpilot’s brand-wide 2.5 from 536 is not specific to this product.
Why it might work
Protease and peptidase enzymes break proteins into smaller peptides, amylase and glucoamylase act on starch, lipases on fat, lactase on lactose, alpha-galactosidase on the sugars in beans and some vegetables, and bromelain is a protease from pineapple. The idea is that taking them with a meal adds to the enzymes the body already makes, so less undigested food reaches the colon and produces gas. Trials of enzyme blends in functional dyspepsia are small and mostly use blends of a different makeup, and the trials of alpha-galactosidase give mixed results depending on the meal and the person. The label gives activity units rather than milligrams per enzyme, so the dose of any one enzyme cannot be matched to a trial.
What the research supports
No trial of this product was found, and no ingredient on the current panel is a branded, separately studied ingredient. The closest evidence is for other multi-enzyme blends: a placebo-controlled trial of 120 adults with functional dyspepsia (400 mg a day of a fungal enzyme blend for two months) and another of 40 patients (150 mg a day for 60 days) each improved dyspepsia scores, in different formulas at different doses, and the second was run by the maker of its blend. The studies the brand lists on its page are about wound debridement, exercise recovery and bromelain, not bloating.
What the label discloses
Eighteen enzyme lines are listed with activity units, but the two blends carry only a combined weight (213.9 mg and 357.6 mg), and the protease total is 322,000 HUT per three-capsule serving. The brand’s “4x more” comparison is against five unnamed products using their own label figures. The brand states tens of thousands of in-house laboratory and quality tests, but no independent testing body or certificate was found.
Who this tends to suit
We match this product to people reporting bloating, gas, symptoms that follow particular foods and general abdominal discomfort. It fits someone whose priority is handling meals or day-to-day comfort. Whether it is the best fit for you depends on the rest of your answers — what you have already tried, what format you will take, and anything that has to be ruled out.
Where it may not fit
The label supports vegan, gluten-free, dairy-free and no added sweeteners. We flag this product for anyone pregnant or breastfeeding or taking prescription medication, and the quiz removes it rather than recommending it in those cases. That is a caution about who should be deciding, not a claim about the product. A capsule only works if you will take it as often as the label directs.
Side effects and what to be aware of
Reviewers who were not helped say it did nothing or was not worth the price, and about 100 Amazon reviews mention side effects. The brand says not to use it with ulcers or gastritis, to check with a clinician if pregnant, nursing, taking medication (including blood thinners) or under medical supervision, and it is not recommended in pregnancy or breastfeeding. Trustpilot reviews about the brand as a whole include orders shipping after a subscription was cancelled. The 365-day guarantee no longer applies once a second bottle is opened.
Common questions
Does MassZymes work for bloating?
No trial of MassZymes was found. Placebo-controlled trials of other multi-enzyme blends in functional dyspepsia (120 adults on 400 mg a day for two months; 40 patients on 150 mg a day for 60 days) improved dyspepsia scores, and a trial of alpha-galactosidase alone helped bloating in IBS patients sensitive to high-GOS foods, while another trial of that enzyme in IBS did not beat placebo. Amazon reviewers report easing of bloating after meals (4.5 from 2,596 ratings); a minority report no effect.
What are the MassZymes side effects, and is it safe?
The brand says to avoid it with ulcers or gastritis, not to use it in pregnancy or breastfeeding, and to ask a practitioner first if taking medication, since some enzymes may interact with blood thinners. It contains bromelain, which at higher doses can cause mouth tingling, diarrhea or upset stomach and may raise bleeding risk with anticoagulants. About 100 Amazon reviews mention side effects.
How much does MassZymes cost per day?
A 250-capsule bottle is $59.99 on the brand’s site (about $0.72 per three-capsule serving), the 120-capsule bottle is $34.99 ($0.87 per serving), and Amazon lists the 120-capsule bottle at $34.45. The label allows one to three capsules before each meal, so three servings a day would be $2.16 to $2.62. Subscribing takes an extra 12% off on the brand’s site.
MassZymes vs other digestive enzymes: what is different?
Its label lists 18 enzymes with 322,000 HUT of protease per three-capsule serving, which the brand compares with five unnamed competitors (37,000 to 80,000 HUT in the three that list protease). The panel groups the enzymes into two blends and does not give milligrams per enzyme, and no trial compares it with another product.
What is the BIOptimizers refund policy?
BIOptimizers of Reno, Nevada offers a 365-day money-back guarantee for unopened bottles; if a second bottle is opened, the guarantee no longer applies, and the first bottle of a product counts as a trial. Trustpilot shows 2.5 from 536 reviews for the brand as a whole, with complaints about orders shipping after cancellation and refunds limited to unopened bottles, and the company replies to negative reviews. Amazon purchases are marked non-returnable.
Before you take this. Speak to a doctor or pharmacist first if you are pregnant or breastfeeding, or taking prescription medication. Nothing on this page is medical advice, and no supplement diagnoses, treats, cures or prevents disease.
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Others we researched for the same job
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Related reading
Background on how this type of product works, read from the trial evidence.