Daily gut routine
Microbiome Plus+ Gastrointestinal Combo (L. reuteri NCIMB 30242 and scFOS)
A twice-daily kit of one named L. reuteri capsule and a 600 mg scFOS fiber tablet, taken with meals.
- Format
- Capsule
- Type
- Probiotic and prebiotic
- Cost
- $2.20 per day for two capsules and two tablets; the capsule alone is about $1.75 a day
- Customer rating
- 4.8 out of 5 from 298 ratings from microbiomeplus.com
What customers consistently report
- Lower LDL and total cholesterol numbers on blood tests
- Less gas and bloating within a few weeks
- A capsule and tablet that are easy to swallow
Those are the themes that recur across the reviews. Moderate review confidence — the 4.8 from 298 reviews is a pooled score shown only on the brand’s own Loox widget for two products, Trustpilot shows 4.0 from 51 for the whole brand, and the independent Amazon rating (4.4 from 714) belongs to the single-strain capsule, not this kit.
Why it might work
L. reuteri NCIMB 30242 makes an enzyme called bile salt hydrolase, which frees bile acids; in trials this reduced cholesterol absorption, which is why most of the strain’s evidence is about LDL and not the gut. The delayed-release capsule is meant to carry the bacteria past stomach acid, and the brand says the strain is thought to add to the gut’s own populations while it is taken. scFOS is a short-chain fiber that gut bacteria ferment, which the brand calls food for the probiotic, but 600 mg per tablet is small next to the grams used in studies and fermenting fibers can cause gas in some people. A result for one strain does not carry to another. The label does not show how many bacteria are alive at expiry or what the manufacturer’s tests found.
What the research supports
No trial of this kit was found. The strain in the capsule, L. reuteri NCIMB 30242, has seven human-study papers from one research group; the main trial, in 127 adults with high cholesterol, lowered LDL by 11.6% against placebo over 9 weeks, and a post hoc look at the same trial found better general gut-health scores and fewer diarrhea symptoms. Constipation and bloating were not reported as improved, and reviews of probiotics in constipation and IBS rate the evidence for mixed or combined products as low. The tablet gives 1.2 g of scFOS a day, below the 2.5 g that did not change bifidobacteria in a dose-response trial.
What the label discloses
One strain, named by its culture-collection code, at 3.5 billion CFU per capsule, with a printed CFU figure but no statement of the count at expiry. The capsule is delayed release and shelf stable, and the brand names no laboratory for its third-party-tested claim, though Amazon links a certificate of analysis for the single-strain version. The kit is two containers, and the page’s per-capsule price counts the tablets as capsules. The allergen statement names the capsule and not the tablet.
Who this tends to suit
We match this product to people reporting bloating, general abdominal discomfort and irregular bowel habits. It fits someone whose priority is day-to-day comfort or a steady daily routine. Whether it is the best fit for you depends on the rest of your answers — what you have already tried, what format you will take, and anything that has to be ruled out.
Where it may not fit
The label supports gluten-free, dairy-free and no added sweeteners. We flag this product for anyone pregnant or breastfeeding or taking prescription medication, and the quiz removes it rather than recommending it in those cases. That is a caution about who should be deciding, not a claim about the product. A capsule only works if you will take it as often as the label directs.
Side effects and what to be aware of
A reviewer was surprised the kit is two bottles, and several mention slow or lost deliveries; Trustpilot’s most common complaint is delivery, with one reviewer disputing a charge after an undelivered order. The label advises consulting a physician if pregnant, nursing, under 18 or with a medical condition, and the single-strain Amazon listing adds prescription medication.
Common questions
Does Microbiome Plus+ L. reuteri and scFOS work for gut symptoms?
No trial of this kit was found. The strain, L. reuteri NCIMB 30242, lowered LDL by 11.6% in a 127-person trial, and a post hoc analysis of that trial found better general gut-health scores and fewer diarrhea symptoms (p = 0.029 and 0.018) in people without a gut condition. Reviews of probiotics in IBS and constipation rate the evidence for combination products as low.
Is Microbiome Plus+ safe, and what are the side effects?
The label advises talking to a physician first if you are pregnant, nursing, under 18 or have a medical condition. A 131-person, 9-week safety trial of the strain at 2.9 billion CFU twice daily found adverse events similar to placebo, and the kit gives 3.5 billion twice daily. The scFOS tablet is a fermentable fiber, and trials of FOS record mild bloating and gas.
How much does Microbiome Plus+ cost?
The kit is $61.49 for 28 days, about $2.20 a day for two capsules and two tablets, and $52.27 a pack on a standard subscription (about $1.87 a day). The capsule alone is $48.99 on the brand site and $49.99 on Amazon.
Microbiome Plus+ vs a multi-strain probiotic: how do they differ?
Microbiome Plus+ uses one named strain at 3.5 billion CFU twice daily, with a 600 mg fiber tablet. Multi-strain products usually list more organisms in one capsule, and a 2022 review found stool-frequency gains for B. lactis alone but not for mixtures. No trial compares the two kinds.
Can you cancel Microbiome Plus+ and get a refund?
The brand says subscriptions can be skipped or canceled online or by phone and offers a one-year money-back guarantee, with a phone call and a return to its Vancouver address first. Trustpilot (4.0 from 51) lists delivery as the most common complaint, and one reviewer disputed a charge after an undelivered order. Amazon purchases follow Amazon’s rules.
Before you take this. Speak to a doctor or pharmacist first if you are pregnant or breastfeeding, or taking prescription medication. Nothing on this page is medical advice, and no supplement diagnoses, treats, cures or prevents disease.
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Others we researched for the same job
These sit in the same role as Microbiome Plus+ Gastrointestinal Combo (L. reuteri NCIMB 30242 and scFOS) — daily gut routine — so they are the sensible things to weigh it against.
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Related reading
Background on how this type of product works, read from the trial evidence.