Taken with meals
Nutreance ElevenZyme Digestive Enzyme Formula
An 11-enzyme capsule in a 110 mg blend, taken before the largest meal of the day.
- Format
- Capsule
- Type
- Digestive enzyme
- Cost
- $1.33 per capsule; the bottle says one capsule once or twice a day
- Customer rating
- 4.2 out of 5 from 402 ratings from Amazon
What customers consistently report
- Less bloating and gas after meals
- Eating out and trigger foods with less trouble
- A small capsule that is easy to take
Those are the themes that recur across the reviews. Moderate review confidence — Amazon shows 4.2 from 402 independent ratings, but the brand’s 4.5 from 64 ratings is hosted by its own site rather than a review app, and the Trustpilot profile for nutreance.com covers the whole company, not this product.
Why it might work
Digestive enzymes are proteins that cut food molecules into smaller pieces before absorption. This label lists three proteases and a peptidase for protein, amylase, glucoamylase, invertase and acid maltase for starch and sugar, lipase for fat, lactase for milk sugar, and alpha-galactosidase, which cuts the sugars in beans and cabbage. The idea is that less undigested food reaches the gut bacteria that ferment it into gas. The brand says the three proteases work at different acidity levels along the digestive tract. Enzyme activity on a label is measured in a laboratory, not in a stomach, and the capsule is not stated to be delayed release. The label does not show how much of the 110 mg is enzyme protein, and the amounts are lower than several other enzyme capsules on the units that can be compared.
What the research supports
One sponsor-commissioned study exists: 52 adults with self-reported gas and bloating, 32 on the capsule and 20 on placebo, single-blind for 4 weeks, with 90.6% of the enzyme group agreeing they had less gas and 96.9% less bloating. Half of the placebo group (10 of 20) also agreed they had less gas and less bloating, no baseline symptom score was taken, and the report shows no statistical tests. It used 2 capsules before the largest meal, where the bottle says 1 capsule once or twice a day. The enzymes are not branded, and the nearest outside evidence is a 120-person trial of a different fungal enzyme blend at 400 mg a day in functional dyspepsia; this blend is 110 mg per capsule.
What the label discloses
All eleven enzymes carry a printed activity unit, which allows a comparison with other products, but they share one 110 mg proprietary-blend weight, so the amount of each enzyme is not listed, and the unit for the 4,000 “PC” protease is not defined. The bottle states no allergen or free-from information beyond vegan and non-GMO. The brand describes a GMP-certified New York facility and in-house testing but names no outside laboratory and posts no certificate of analysis.
Who this tends to suit
We match this product to people reporting bloating, gas, symptoms that follow particular foods and general abdominal discomfort. It fits someone whose priority is handling meals or day-to-day comfort. Whether it is the best fit for you depends on the rest of your answers — what you have already tried, what format you will take, and anything that has to be ruled out.
Where it may not fit
The label supports vegan. We flag this product for anyone pregnant or breastfeeding or taking prescription medication, and the quiz removes it rather than recommending it in those cases. That is a caution about who should be deciding, not a claim about the product. A capsule only works if you will take it as often as the label directs.
Side effects and what to be aware of
Amazon reviewers split on whether it works (24 of 57 effectiveness mentions are negative), 14 of 17 value mentions are negative, and some report stomach pain, nausea or heartburn. The bottle says not to use it if pregnant or nursing and to consult a doctor if taking medication, and Amazon lists the item as non-returnable.
Common questions
Does Nutreance ElevenZyme work?
One sponsor-funded study of 52 adults found 96.9% of the enzyme group (31 of 32) agreed they had less bloating after 4 weeks, but 50% of the placebo group (10 of 20) agreed too, and no baseline scores or statistical tests are reported. On Amazon it holds 4.2 from 402 ratings, and reviewers are split: 33 of 57 effectiveness mentions are positive.
What enzymes are in ElevenZyme and how much of each?
Eleven: amylase 3,500 DU, three proteases (21,000 HUT, 4,000 PC, 50 SAPU), alpha-galactosidase 150 GalU, glucoamylase 9 AGU, lactase 1,000 ALU, invertase 400 SU, lipase 500 FIP, acid maltase 14 MaltU and peptidase 2 AP, all in a 110 mg blend per capsule. The label gives activity units but not the milligrams of each enzyme.
How much does ElevenZyme cost per day?
A 30-capsule bottle is $39.95 on the brand site and on Amazon, or $1.33 a capsule. The bottle says one capsule once or twice a day, which is $1.33 to $2.66 a day; one before every meal is $4.00. Amazon’s Subscribe & Save is $37.95, and the brand site states no subscription discount.
ElevenZyme vs HoloZyme or Let Loose: how do the enzymes compare?
ElevenZyme lists 11 enzymes in 110 mg per capsule, Let Loose 16 in 355 mg and HoloZyme 15. On units that share a name ElevenZyme is lower on protease, lipase, alpha-galactosidase and amylase, higher than Let Loose on lactase (1,000 vs 400 ALU) but lower than HoloZyme (3,000), and has no cellulase or xylanase. It costs $1.33 a capsule against $0.93 and $0.83.
What are the side effects of ElevenZyme, and can I get a refund?
The bottle says not to use it if pregnant or nursing and to consult a doctor if taking prescription medication. The brand’s own Safety Facts page lists possible stomach upset, headache, diarrhea and flatulence, and some Amazon reviewers report stomach pain, nausea or heartburn. The brand offers a 30-day refund of one opened bottle, while Amazon lists the item as non-returnable.
Before you take this. Speak to a doctor or pharmacist first if you are pregnant or breastfeeding, or taking prescription medication. Nothing on this page is medical advice, and no supplement diagnoses, treats, cures or prevents disease.
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Others we researched for the same job
These sit in the same role as Nutreance ElevenZyme Digestive Enzyme Formula — taken with meals — so they are the sensible things to weigh it against.
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Related reading
Background on how this type of product works, read from the trial evidence.