Guide

Does Nutreance ElevenZyme work? Eleven enzymes in 110 mg, and a sponsor study where half the placebo group improved too

Nutreance ElevenZyme is a vegetable capsule of eleven digestive enzymes, sold for bloating, gas and indigestion and taken before the largest meal of the day. Its label prints an activity unit for every enzyme, so it can be read against other enzyme labels, and the brand links a study of the capsule itself. This page sets out what is printed, what the study measured, and how the units, reviews and refund terms compare.

What ElevenZyme is, and what it is not

One capsule holds a 110 mg “ElevenZyme Proprietary Blend” with the activity of each enzyme printed in parentheses. The other ingredients are microcrystalline cellulose, the capsule and magnesium stearate. There are no probiotics or herbs. The bottle carries “Vegan” and “Non GMO” badges and no allergen statement of any kind.

The eleven enzymes share one blend weight, so the milligrams of each, and how much of the 110 mg is enzyme protein at all, cannot be read. The label does not say which of the three proteases carries which unit, and it does not define “PC”. Enzyme units are laboratory measures, and suppliers do not always use the same assay behind the same abbreviation. An Amazon reviewer wrote that it contains lactose; the panel lists lactase, the enzyme, not lactose.

The brand’s study of the capsule

The brand’s page calls ElevenZyme “clinically proven” and describes a placebo-controlled study of 52 participants with “statistically significant” results; those are the brand’s words. The report it links, prepared for Nutreance by a commercial research firm in 2024, shows this.

• Design: a single-blind, home-use study of 52 adults aged 40 to 65 with self-assessed gas, bloating, heartburn or indigestion and no diagnosed digestive disorder. 32 took ElevenZyme and 20 took placebo for four weeks. All 52 finished.
• Measure: one questionnaire at the end, asking whether people agreed with statements such as having less frequent or less intense bloat. No symptom score was taken at the start.
• Results: 90.6% of the enzyme group (29 of 32) agreed they had less gas and 96.9% (31 of 32) less bloating. In the placebo group 50% (10 of 20) agreed to each. For heartburn the figures were 84.4% against 45%, for digestive discomfort 96.9% against 30%.
• Statistics: the 55-page report shows no p-values, confidence intervals or statistical tests.
• Registration: we found no entry on ClinicalTrials.gov or PubMed.

The brand page quotes only the enzyme-group figures. Half of the group taking an inactive capsule also agreed that bloating and gas had eased, so the gap between the groups is what the study can speak to, and with 20 people in one arm and no starting score it cannot show how large that gap is.

The study dose also differs from the label. Participants took two capsules before the largest meal. The bottle says one capsule once or twice a day, and the brand’s FAQ says one capsule before the largest meal. One Amazon reviewer pointed out that following the study directions empties a bottle in about two weeks.

The evidence for multi-enzyme blends

None of ElevenZyme’s enzymes carries a brand name, and the brand cites one unnamed study per enzyme with no author, journal or link, so none could be checked. The nearest outside trial is a double-blind study of 120 adults with functional dyspepsia given a fungal-fermentation multi-enzyme blend at 400 mg a day or placebo for two months; dyspepsia-index, pain and sleep scores improved more on the enzymes. ElevenZyme supplies 110 mg per capsule, so one to two capsules is 110 to 220 mg of a different blend. A 40-patient trial of another branded blend at 150 mg a day for 60 days also favored the enzymes, with authors tied to its maker. A crossover trial of 25 adults given 18 enzymes plus herbs before pizza found a smaller rise in waist measurement but no difference in self-reported bloating.

Alpha-galactosidase has the most specific trials. In 8 healthy volunteers eating a bean meal, 1,200 GalU lowered breath hydrogen and flatulence and 300 GalU lowered the symptom score. Trials in 125 and 20 people with irritable bowel syndrome, the second at 1,200 GalU per meal, found no routine benefit. One ElevenZyme capsule supplies 150 GalU. We found no trial pinned to its 1,000 ALU of lactase, and none testing eleven enzymes at 110 mg against a larger or smaller blend. The digestive enzymes guide covers where single enzymes have trial support.

ElevenZyme against Let Loose, HoloZyme and Digest Gold

Per capsule, ElevenZyme against Let Loose, HoloZyme and Digest Gold:

• Protease (HUT): 21,000 against 70,000, 100,000 and 80,000. ElevenZyme also lists 4,000 PC and 50 SAPU.
• Lipase (FIP): 500 against 1,400, 700 and 4,000.
• Alpha-galactosidase (GalU): 150 against 300, 650 and 450.
• Amylase (DU): 3,500 against 12,000 and 23,000; HoloZyme prints amylase in a different unit.
• Lactase (ALU): 1,000 against 400, 3,000 and 900, so higher than two of the three.

ElevenZyme has no cellulase or xylanase, which all three others carry. It lists 11 enzymes against 16, 15 and 13, and a 110 mg blend against Let Loose’s 355 mg; HoloZyme and Digest Gold print no blend weight. None of the three others has a trial of its own formula.

How to take ElevenZyme

The bottle says one capsule once or twice daily. The brand’s FAQ recommends one capsule 20 to 30 minutes before the largest meal, one before every meal for bigger problems, and no more than six a day. The brand recommends staying with the product at least 90 days; no trial tests that, and the study ran four weeks.

Side effects and who should check first

The bottle says not to use it if pregnant or nursing, and to consult a doctor first with a pre-existing condition or a prescription medication. The brand’s Safety Facts page softens this, saying pregnant and nursing women should have a physician’s approval and that the capsule can be taken with most prescription and over-the-counter medications. It lists possible side effects of stomach upset, headache, sweating, rash, diarrhea, flatulence, itching and skin irritation,. The brand FAQ says no harmful side effects have been reported. Amazon reviewers do report some: in the review summary, 10 of 17 side-effect mentions are negative, naming heartburn, nausea, stomach pain and diarrhea.

What the reviews say

• Amazon: 4.2 from 402 ratings (62% five-star, 16% four, 10% three, 3% two, 9% one). In the mention counts, 33 of 57 effectiveness mentions are positive and 24 negative; for value, 3 are positive and 14 negative.
• Brand site: 4.5 from 64 ratings, run on the brand’s own code rather than a review app. Its one-star filter returned no reviews although the bar chart shows 2%.
• Trustpilot: the profile covers the whole company, not this product. One-star reviews there mostly concern refunds and cancellations on other products in the range.

Reviewers praise less bloating and gas, easier restaurant meals and a small capsule; they complain about price, no effect, and stomach upset.

Price, refunds and returns

A 30-capsule bottle is $39.95 on the brand site and on Amazon, or $1.33 a capsule. At the bottle’s directions that is $1.33 a day at one capsule and $2.66 at two; the study dose of two a day is the latter. One before each meal is $4.00, and the six-capsule maximum $7.99. Amazon’s Subscribe & Save price is $37.95; the brand site offers optional auto-delivery and states no subscription discount. Let Loose is $0.93 a capsule, HoloZyme $0.83 and Digest Gold $0.45.

The brand’s return policy allows one empty or opened bottle to be returned within 30 days for a refund less shipping and handling, with unlimited returns of sealed bottles. Amazon lists the item as non-returnable for food safety reasons unless damaged or defective. One Amazon reviewer reports being unable to get a refund; the Trustpilot refund complaints do not name this product.

Who ElevenZyme is for

• Someone whose trigger meals involve dairy, starch or beans, knowing the alpha-galactosidase trials in IBS are mixed and the label supplies a fraction of the trial doses.
• Someone who wants a unit printed for each enzyme to compare labels.
• Someone who can take a capsule before one or two meals a day for several weeks.

For bloating that does not follow particular meals, the enzymes against probiotics guide compares the approaches, and the quiz starts from symptoms.

The products in this catalog

Common questions

Sources

• Princeton Consumer Research (PCR Corp). Study NUTUSE11M, final report prepared for Nutreance, 2024: design, dose, questionnaire results. princetonconsumerresearch.com/studies/NUTUSE11M.pdf
• Ullah H, et al. A multi-enzyme blend from fungal fermentation in 120 adults with functional dyspepsia: randomized, double-blind, placebo-controlled trial. Biomedicine and Pharmacotherapy, 2023. PMID 37976892
• Majeed M, et al. DigeZyme multi-enzyme supplement in 40 patients with functional dyspepsia. Journal of Medicinal Food, 2018. PMID 30156436
• Martin-Biggers J, et al. A multi-digestive enzyme and herbal dietary supplement and post-meal bloating: double-blind crossover trial. Nutrition and Dietary Supplements, 2024. doi.org/10.2147/NDS.S453377
• Di Stefano M, et al. Alpha-galactosidase and gas after a bean meal in 8 healthy volunteers. Digestive Diseases and Sciences, 2007. PMID 17151807
• Hillila M, et al. Alpha-galactosidase in 125 patients with irritable bowel syndrome. Scandinavian Journal of Gastroenterology, 2016. PMID 26133538
• Bohn L, et al. Alpha-galactosidase in 20 patients with irritable bowel syndrome. Neurogastroenterology and Motility, 2021. PMID 33619835
• Nutreance brand pages: product page, Safety Facts, quality control and return policy; bottle photograph for the Supplement Facts panel and warnings. nutreance.com/products/elevenzyme; safety facts; return policy
• Amazon listing: rating, star split, review summary, price and return terms. amazon.com/dp/B0BCH1W3W8
• NIH Dietary Supplement Label Database: Enzymedica Digest Gold label; HoloZyme and Let Loose Supplement Facts on the brand pages, used for the unit comparison. dsld.od.nih.gov/label/328881; healthygut.com/products/holozyme; takeletloose.com/products/koji-digestive-enzymes